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Local Anaesthetic Systemic Toxicity (LAST)

AAGBI Intralipid Dose Calculation for Management of LAST

Rapid Intralipid Dose Calculation for Management of LAST1

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Dose calculations for AAGBI guidelines for a patient weight of 70kg

- Give ml as a bolus over 1 min (1.5ml.kg-1)

- Then commence a ml/hr infusion (15ml.kg-1.hr-1).


Reassess after 5 minutes, if

  • cardiovascular stability has not been restored or
  • an adequate circulation deteriorates

May give a maximum of 2 further repeat boluses of ml (1.5ml.kg-1 x 3).

And may double the rate of infusion at ay time after 5 min to ml/hr (30ml.kg-1.hr-1.)

Do not exceed a maximum dose of mls (12ml.kg-1).

References

  1. AAGBI Management of Severe Local Anaesthetic Toxicity - 2010
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